专利名称：ANTIBODIES TO HUMAN PROGRAMMED
DEATH RECEPTOR PD-1
发明人：CARVEN, Gregory, John,VAN EENENNAAM,
Hans,DULOS, Gradus, Johannes
申请号：EP08768485.8申请日：20080613公开号：EP2170959A1公开日：20100407
摘要：Antibodies which block the binding of human Programmed Death Receptor 1(hPD-1) to its ligands (hPD-L1 or hPD-L2) and their variable region sequences aredisclosed. A method of increasing the activity (or reducing downmodulation) of animmune response through the PD-1 pathway is also disclosed.
申请人：N.V. Organon
地址：Kloosterstraat 6 5349 AB Oss NL
国籍：NL
代理机构：van Wezenbeek, Petrus M.G.F.
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