Product Data SheetProduct Name:CAS No.: CatNo:Cat. No.:MWt:Formula:Purity :Salbutamol hemisulfate51022-70-9HY-B0436HYB0436239.31C13H21NO3>98%Solubility:DMSO<1mg/mL;Water68mg/mLDMSO <1 mg/mL; Water 68 mg/mLMechanisms: Pathways:GPCR/G protein; Target:Adrenergic Receptor Biological Activity:Salbutamol Hemisulfate is a short-acting β2adrenergic receptor agonistTarget: β2 Adrenergic Receptor Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment ofasthma and COPD. All the effects of R,S-salbutamol on guinea-pig skeletal muscles are due to theactivity of the R-enantiomer. Thus there is a common enantiomeric profile for the skeletal muscleand bronchorelaxant activity of the compound [1]. Short-term Salbutamol intake did appear toimprove performance during intense submaximal exercise with concomitant increase in substrateavailability and utilization, but the exact mechanisms involved need further investigation [2]. Short-termadministrationofsalbutamolincreasesvoluntarymusclestrengthinmanHowevertheterm administration of salbutamol increases voluntary muscle strength in man. However, themagnitude and duration of this effect vary between muscle groups. This study implies that the beta2-adr...References:[1]. Prior, C., M.B. Leonard, and J.R. McCullough, Effects of the enantiomers of R,S-salbutamol onincompletely fused tetanic contractions of slow- and fast-twitch skeletal muscles of the guinea-pig.Br J Pharmacol, 1998. 123(3): p. 558-. [2]Cll[2]. Collomp, K., et al., Effects of short-term oral salbutamol administration on exercise enduranceKtlEfftfhttllbtldiittiidand metabolism. J Appl Physiol (1985), 2000. (2): p. 430-6. [3]. Martineau, L., et al., Salbutamol, a beta 2-adrenoceptor agonist, increases skeletal musclestrength in young men. Clin Sci (Lond), 1992. 83(5): p. 615-21. Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 080,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com
