Bicyclic amidines and their use as catalysts

专利名称：Bicyclic amidines and their use as catalysts发明人：WERBITZKY, OLEG, DR.,DAUM, ULRICH,

DR.,BREGY, RACHEL

申请号：EP98110227.0申请日：19941110公开号：EP0869127B1公开日：20011010

摘要：Bicyclic amidines of formula (I) prepn. comprises: a) heating a lactone of formula(II) to at least 150 degrees C., with an at least equimolecular amt. of an amine of formula(III): b) isolating the prod. by distn., without isolation of an intermediate: (III) H2N-B-NH2.A = CR<1>R<2>-CR<3>R<4>-CR<5>R<6>-, -CR<1>R<2>-CR<3>R<4>-CR<5>R6-CR<7>R<8>, -CR<1>R<2>-CR<3>R<4>-CR<5>R<6>- CR<7>R<8>-CR<9>R<10>; B =CR<11>R<12>-CR<13>R<14>-, -CR<11>R<12>-CR<15>R<16>-CR<13>R<14>, -CR<11>R<12>-CR<15>R<16>-CR<17>R<18>-CR<13>R<14>; R<1>, R<2> and R<11>= H, 1-4C alkyl opt. substd. with OH or amino, aryl or 1-4C alkylamino or mercapto; andR<3-10> and R<15>-<18> = H, 1-4C alkyl, aryl, OH, amino, 1-4C alkylamino or mercapto,or 1-4C alkyl substd. with OH, amino or 1-4C alkylamino or mercapto. Also claimed are:(a) a bicyclic amidine; (b) new cpd.: 3-amino-2,3,4,6,7,8-hexahydropyrrolo(1,2-a)-pyrimidine(IV); (c) 3-(aminomethyl)2,5,6,7-tetrahydro-3H-pyrrolo(1,2-a)imidazole (V); and (d) 3-(aminomethyl)-3,2,3,4,6,7,8-hexahydropyrrolo(1,2-a)pyrimidine (VI); and (e) use of a bicyclicamidine as a catalyst.

申请人：LONZA AG,LONZA AG,LONZA AG

地址：CH

国籍：CH

代理机构：Winter, Brandl, Fürniss, Hübner, Röss, Kaiser, Polte Partnerschaft

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