专利名称：POLYMERIC NANOPARTICLES AND
METHODS OF MAKING AND USING SAME
发明人：Young Ho SUNG,Greg TROIANO,Hong
WANG,Maria FIGUEIREDO,Michael H.LAM,Caroline MCGREGOR
申请号：US15126894申请日：20150312
公开号：US20170087135A1公开日：20170330
摘要：Described herein are polymeric nanoparticles that comprise 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]-triazolo-[3,4-fJ[1,6]-naphthyridin-3-one(Compound A), or a pharmaceutically acceptable salt thereof, and methods of makingand using such nanoparticles. The nanoparticle comprises about 50 to about 99.8 weightpercent of a diblock poly(lactic) acid-poly(ethylene)glycol copolymer or a diblockpoly(lactic acid-co-glycolic acid)-poly(ethylene)glycol copolymer, wherein the totalamount of poly(ethylene)glycol in the nanoparticle is about 10 to about 30 weightpercent poly(ethylene)glycol and about 0.2 to about 30 weight percent of Compound A.
申请人：MERCK SHARP & DOHME CORP.,BIND THERAPEUTICS, INC.
地址：Rahway NJ US,Cambridge MA US
国籍：US,US
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