专利名称：Viscosity modulating substance and use
thereof
发明人：Carl V. Manion申请号：US10088713申请日：20000921公开号：US06919374B1公开日：20050719
摘要：It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester(APM) lowers whole blood viscosity in patient, including those suffering from sickle celldisease and plasma cell dyscrasias. Upon in vivo APM treatment patients experienced asignificant lowering of whole blood viscosity. In vitro addition of APM to patients sampleshaving elevated whole blood viscosity resulted in reduced viscosity over time. These invivo and in vivo results identify APM as a therapeutic agent for molecular diseases whichlead to elevated whole blood viscosity. A method by which APM treatment can bemonitored is also disclosed.
申请人：Carl V. Manion
地址：Oklahoma City OK US
国籍：US
代理机构：Conley Rose, P.C.
代理人：Eugenia S. Hansen
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