1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE

专利名称：1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES

发明人：José Ignacio Andrés-Gil,Peter Jacobus

Johannes Antonius Buijnsters,Andrés AvelinoTrabanco-Suárez,Meri De Angelis,GretaConstantia Peter Vanhoof,Jérôme EmileGeorges Guillemont,Frederik Jan RitaRombouts,Maarten Vliegen,Guy Maurits R.Bormans,SofleJeanne Leopoldine Celens

申请号：US14128835申请日：20120626

公开号：US20140147386A1公开日：20140529

摘要：The present invention relates to novel 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]-quinoxaline derivatives as inhibitors of phosphodiesterase 2 (PDE2) and to a lesser extentof phosphodiesterase 10 (PDE10) or as inhibitors of both, phosphodiesterases 2 and 10.The invention is also directed to pharmaceutical compositions comprising such

compounds, to processes for preparing such compounds and compositions, and to theuse of such compounds and compositions for the prevention and treatment of disordersin which PDE2 is involved, or disorders in which both PDE2 and PDE 10 are involved, suchas neurological and psychiatric disorders, and endocrinological or metabolic diseases.The present invention also relates to radiolabelled compounds which may be useful forimaging and quantifying the PDE2 enzyme in tissues, using positron-emission tomography

(PET). The invention is also directed to compositions comprising such compounds, toprocesses for preparing such compounds and compositions, to the use of such

compounds and compositions for imaging a tissue, cells or a host, in vitro or in vivo and toprecursors of said compounds.

申请人：José Ignacio Andrés-Gil,Peter Jacobus Johannes Antonius Buijnsters,AndrésAvelino Trabanco-Suárez,Meri De Angelis,Greta Constantia Peter Vanhoof,Jérôme EmileGeorges Guillemont,Frederik Jan Rita Rombouts,Maarten Vliegen,Guy Maurits R.Bormans,SofleJeanne Leopoldine Celens

地址：Toledo ES,Beerse BE,Toledo ES,Munich DE,Beerse BE,Val de Reuil CedexFR,Beerse BE,Beerse BE,Leuven BE,Leuven BE

国籍：ES,BE,ES,DE,BE,FR,BE,BE,BE,BE

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