Method of making camptothecin and camptothecin ana

专利名称：Method of making camptothecin and

camptothecin analogs

发明人：The designation of the inventor has not yet

been filed

申请号：EP99112300.1申请日：19911218公开号：EP0963988A2公开日：19991215

摘要：Compounds of Formula I are made in accordance with the following scheme:wherein R may be loweralkyl; R may be H, loweralkyl, loweralkoxy, or halo; R, R, R, and Rmay each independently be H, amino, hydroxy, loweralkyl, loweralkoxy, loweralkylthio,di(loweralkyl)amino, cyano, methylenedioxy, formyl, nitro, halo, trifluoromethyl,

aminomethyl, azido, amido, hydrazino, or any of the twenty standard amino acids bondedto the A ring via the amino-nitrogen atom; Y is H and W and X are halogen. Also disclosedare novel processes for making starting materials for the scheme given above, and novelintermediates employed in these processes.

申请人：NORTH CAROLINA STATE UNIVERSITY

地址：103 Holladay Hall, Campus Box 7003 Raleigh, North Carolina 27695-7003 US

国籍：US

代理机构：Horner, Martin Grenville

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