Method for non-invasive prenatal diagnosis

专利名称：Method for non-invasive prenatal diagnosis发明人：ROSSA WAI-KWUN CHIU,CHARLES R.

CANTOR,YUK MING DENNIS LO,CHUNMINGDING

申请号：AU2004270220申请日：20040907公开号：AU2004270220A1公开日：20050317

摘要：The present invention is directed to methods of detecting nucleic acids in abiological sample. The method is based on a novel combination of a base extensionreaction, which provides excellent analytical specificity, and a mass spectrometric analysis,which provides excellent specificity. The method can be used, for example, for diagnostic,prognostic and treatment purposes. The method can be used, for example, for

diagnostic, prognostic and treatment purposes. The method allows accurate detection ofnucleic acids that are present in very small amounts in a biological sample. For example,the method of the present invention is preferably used to detect fetal nucleic acid inmaternal blood sample; circulating tumor-specific nucleic acids in a blood, urine or stoolsample; and donor-specific acids in transplant recipients. In another embodiment, one candetect viral, bacterial, fungal, or other foreign nucleic acids in biological sample.

申请人：THE TRUSTEES OF BOSTON UNIVERSITY,THE CHINESE UNIVERSITY OF HONGKONG

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